Polyautoimmunity and Helminthic Therapy
Autoimmune diseases often cluster within the same individual and family. This article examines helminthic therapy through the lens of immune training, microbiome ecology, and transgenerational biology, exploring evidence that the absence of co-evolved organisms may contribute to immune dysregulation across diseases and generations. It reviews current research on regulatory T cells, the microbiome-immune axis, maternal transmission, and the broader implications of biome depletion for understanding autoimmune disease.