Pernicious anemia is one of the clearest cases in contemporary medicine where everything required for good outcomes exists — the diagnostic tools, the treatment, the evidence base — and the outcomes remain poor anyway. The gap between what medicine knows and what medicine does is not a gap in knowledge.
Diagnosis of Pernicious Anemia
PHYSICIAN REFERENCE: Pernicious Anemia
Pernicious anemia is a demyelinating neurological disease. Vitamin B12 malabsorption leads to central and peripheral nerve damage, neurological and psychiatric symptoms that often precede anemia, and recovery limits set by the biology of myelin repair rather than blood test normalization.