Here is the Part IV cover page as a clean, standalone block.
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Part IV — Mechanistic Appendices and Evidence Framework
Part IV provides the analytical backbone that supports the ecological interpretation and the Gate architecture. These appendices document the mechanistic domains—microbial ecology, epithelial biology, bile-acid chemistry, redox systems, immune signaling, motility, and neuroenteric regulation—that underpin the entire restoration model.
This section also formalizes the graded evidence structure used across the document. Human clinical findings anchor interpretation; conserved animal mechanisms fill structural gaps; in-vitro data clarify biochemical pathways; explicit inferences are restricted to cases where measured data are insufficient but mechanisms are well established.
Each appendix isolates a domain, defines the relevant mechanisms, maps system interactions, and identifies boundaries and uncertainties. Together, they ensure internal coherence, transparent evidence use, and reproducible reasoning.
→ Part IV provides the mechanistic and evidentiary infrastructure that makes the ecological and clinical interpretation both rigorous and traceable.
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If you need a unified cover page for the entire project as well, I can generate that next.