Evidence-Based Information and Analysis
Gut Foundational Reference Laurel Fitzhugh — September 16, 2026 | Status: Working document The gut system is the second major constitutional factor in this clinical picture. It is tightly coupled to the CNS system through the gut-vagus connection and through continuous inflammatory signaling originating at the intestinal barrier. LPS translocation increases the inflammatory load while … Read more
Iron-Triggered Dysbiosis — Working Hypothesis and Current Status Laurel Fitzhugh — September 16, 2026 This document describes the gut system immediately before the 2023–2024 iron infusions, the infusions themselves as the proximate trigger, the mechanistic reasoning connecting iron exposure to microbiome collapse, and the evidence that led to the working hypothesis that the resulting dysbiotic … Read more
Helminthic Therapy — Personal Reference Laurel Fitzhugh — September 16, 2026 Necator americanus (human hookworm) colonization has been maintained since August 2020. This document covers its mechanism relevant to this patient’s picture, clinical response history, the change in apparent effect following the 2024 escalation, current status, and its relationship to vagus nerve stimulation as a … Read more
Pharmacological Phenotype: Laurel Fitzhugh 20 May 2026 | Updated: September 16, 2026 The Pattern Over decades of managing a complex multi-system autoimmune disease, a consistent and unusual pattern has emerged in how my system responds to medications. The pattern has two distinct components that sometimes appear together and sometimes independently. First, my system frequently responds … Read more
The Root Cause Protocol (RCP) promises a hidden “real” explanation for chronic illness through minerals and metabolism. It attracts many people who have been failed by conventional medicine and who appreciate the use of natural healing practices.
However, this protocol’s sweeping claims and one-size-fits-all approach can and does cause real harm to many.
A practical guide to Erikson’s psychosocial development stages for foster parents and child welfare professionals, with Maslow’s hierarchy as a quick assessment tool.
Pernicious anemia is one of the clearest cases in contemporary medicine where everything required for good outcomes exists — the diagnostic tools, the treatment, the evidence base — and the outcomes remain poor anyway. The gap between what medicine knows and what medicine does is not a gap in knowledge.
A Confused 19th-Century Disease Model Still Shapes Modern Care Pernicious anemia has been misunderstood since it was first described. That misunderstanding did not persist because of a lack of scientific progress, but because early observations hardened into a disease model that medicine never fully revised. The result is a condition that remains misdiagnosed, underdiagnosed, and … Read more
Modern medicine has a reputation for conservatism — slow to accept new ideas, protective of existing paradigms, resistant to challenges from outside the mainstream. That reputation is earned, but it understates the problem. Outright rejection of valid ideas is only one of three distinct mechanisms by which medicine fails its own stated mission. The other two are quieter, carry more institutional cover, and may do more cumulative damage.
Starting B12 treatment for pernicious anemia can sometimes make symptoms feel worse initially—it’s often a sign of nerve repair kicking in. Learn about the myelin rebuilding process, typical timelines for improvement (1-3 months), when to seek medical advice, and essential supplements like omega-3s, choline, and vitamin D to support recovery. Address absorption issues and concurrent deficiencies for optimal healing.
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